For a complete list of publications click here.

On bioRxiv/arXiv:

Karakousi, T., Cristaldi, V., Lopes de Oliveira, M.L., Geraldo, L.H., Gonzalez-Robles, T.J., da Silva, G., Breazeale, A.P., Encarnacion-Rosado, J., Pozniak, J., Kimmelman, A.C., Ruggles, K.V., Marine, J-C., Chandel, N.S., Lund, A.W. IFNg-dependent metabolic reprogramming restrains an immature, pro-metastastic lymphatic state in melanoma. 2024. bioRxiv. doi: 10.1101/2024.12.02.626426.

Paul, S., Yener, B., Lund, AW. C2P-GCN: Cell-to-Patch Graph Convolutional Network for Colorectal Cancer Grading. 2024. arXiv. doi.org/10.48550/arXiv.2403.04962.

Heim, TA, Lin, Z, Steele, MM, Mudianto, T, Lund, AW. CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence. 2023. bioRxiv. doi: 10.1101/2023.02.14.528487.

Published:

Heim, TA, Schultz, AC, Delclaux, I, Cristaldi, V, Churchill, MJ, Ventre, KS, Lund, AW. Lymphatic transport seeds cytotoxic resident memory T cells in skin draining lymph nodes. Science Immunology (2024). 9, eadk8141(2024). doi: 10.1126/sciimmunol.adk8141.

Karakousi, T, Mudianto, T, & Lund, AW. Lymphatic vessels in the age of cancer immunotherapy. Nat Rev Cancer (2024). https://doi.org/10.1038/s41568-024-00681-y

Femel, J., Hill, C., Illa Bochaca, I., Booth, JL., Asnaashari, TG., Steele, M.M., Moshiri, A.S., Do, H., Zhong, J., Osman, I., Leachman, SA., Tsujikawa, T., White, KP., Chang, YH., and Lund, AW. Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma. 2024. Frontiers in Immunology. 15:1328602. doi:10.3389/fimmu.2024.1328602.

Delclaux, I., Ventre, KS., Lund, AW. The tumor-draining lymph node as a reservoir for systemic immune surveillance. 2023. Trends in Cancer. 10(1):28-37. doi.org/10.1016/j.trecan.2023.09.006.

Steele, MM., Dryg, ID., Murugan, D., Femel, J., du Bois, H., Hill, C., Leachman, SA., Chang, YH., Coussens, LM., and Lund, A.W. T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control. 2023. Nature Immunology. doi.org/10.1038/s41590-023-01443-y.

Lund, AW. Immune Potential Untapped: Leveraging the Lymphatic System for Cancer Immunotherapy. 2022. Cancer Res Immunol. doi.org/10/1158/2326-6066.CIR.22.0266.

Churchill, MJ, du Bois, H, Heim, TA, Mudianto, T, Steele, MM, Nolz, JC, Lund, AW. Infection induced lymphatic zippering restricts fluid transport and viral dissemination from skin. 2022. J Exp Med 219(5) e20211830.

du Bois, H, Heim, TA, Lund, AW. Tumor-draining lymph nodes: At the crossroads of metastasis and immunity. 2021. Sci Immunol. 6(63).

Steele, MM, and Lund, AW. Afferent lymphatic transport and peripheral tissue immunity. J Immunol. 2021 Jan 206 (2) 264-272. doi:10.4049/jimmunol.2001060.

Steele MM, Churchill MJ, Breazeale AP, Lane RS, Nelson NA, Lund, AW. Quantifying leukocyte egress via lymphatic vessels from murine skin and tumors. J Vis Exp. 2019 Jan 7;(143).

Lane RS, Femel J, Breazeale, AP, Loo CP, Thibault G, Kaempf A, Mori M, Tsujikawa T, Chang YH, Lund AW. IFNg-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. J Exp Med. 2018 Dec3;215(12):3057-3074.

Lane RS, Lund AW. Non-hematopoietic control of peripheral tissue T cell responses: Implications for solid tumors. Front Immunol. 2018;9:2662.

Loo CP, Nelson NA, Lane RS, Booth JL, Loprinzi Hardin SC, Thomas A, Slifka MK, Nolz JC, Lund AW. Lymphatic vessels balance viral dissemination and immune activation following cutaneous viral infection. Cell Rep. 2017 Sep 26;20(13):3176-3187.

Lund AW. Rethinking lymphatic vessels and anti tumor immunity. Trends Cancer. 2016 Oct;2(10):548-551.

Collaborations:

Broz, M.T., Ko, E.Y., Ishaya, K., Xiao, J., De Simone, M., Hoi, X.P., Piras, R., Gala, B., Tessaro, F.H.G., Karlstaedt, A., Orsuli, S., Balzer, B., Lund, A.W., Chan, K.S., Guarnerio, J. Metabolic targeting of cancer-associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas. 2024. Nature Communications. 15, 2498. doi: 10.1038/s41467-024-46504-4.

Shiva, A., Park, H., Cummings, P., Kim, S., Kim, S., Leong, A., Chowdhury, S., Shawber, C., Lund, A.W., Carvajal, R., Thurston, G., An, J., Yang, H.W., Kim, M. Inhibition of angiopoietin-2 reverses T-cell exclusion and enhances anti-PD-1 therapy in melanoma. 2023. Cancer Research. Jun 15;83(12):1968-1983. Doi: 10.1158/0008-5472.CAN-22-2838.

Were, G, Weissinger, D, Kawaler, EA, Zhao, E, Kalfakakou, D, Dhara, S, Wang, L, Lim, HB, Oh, G, Jing, X, Beri, N, Khanna, L, Gonda, T, Oberstein, P, Hajdu, C, Loomis, C, Heguy, A, Sherman, MH, Lund, AW, Welling, TH, Dolgalev, I, Tsirigos, A, Simeone, DM. Single-cell sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. 2023. Nature Communications. https://doi.org/10.1038/s41467-023-36296-4.

Barkley, D, Moncada, R, Pour, M, Liberman, D, Dryg, I, Werba, G, Wang, W, Baron, M, Rao, A, Xia, B, Franca, GS, Weil, A, Delair, DF, Hajdu, C, Lund, AW, Osman, I, Yanai, I. Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment. 2022. Nature Genetics. https://doi.org/10.1038/s41588-022-01141-9.

Moldoveanu, D., Ramsay, L., Lajoie, M., Anderson-Trocme, L., Bery, D., Lingrand, M., Perus, L., Wei, Y., Moraes, C., Alkallas, R., Rajkuma S., Zuo, D., Najafabadi, HS., Gravel, S., Costantino, S., Richer, MJ., Lund, AW., Del Rincon, SV., Spatz, A., Miller, W., Jamal, R., Lapointe, R., Mes Massons, A., Turcotte, S., Xu, W., Bertos, NR., Petrecca, K., Dumitra, S., Meguerditchian, A., Richardson, K., Tremblay, F., Wang, B., Chergui, M., Guiot, M., Watters, K., Stagg, J., Quail, D., Mihalciou, C., Meterissian, S., Watson, IR. The spatial immune landscape of cutaneous melanoma. 2022 Science Immunology. 7, eabi5072.

Marin-Bejar, O, Rogiers, A, Dewaele, M, Femel, J, Karras, P, Pozniak, J, Bervoets, G, Van Raemdonck, N, Pedri, D, Swings, T, Demeulemeester, J, Vander Borght, S, Bosiso, F, van den Oord, JJ, Vanden Bempt, I, Lambrechts, D, Voet, T, Bechter, O, Rizos, H, Levesque, M, Leucci, E, Lund, AW, Rambow, F, Marine, JC. Evolutionary predictability of genetic versus non-genetic resistance to anticancer drugs in melanoma. 2021. Cancer Cell. 39:1-15.

Ngamcherdtrakul, W, Moataz, R, Nelson, M, Wang, R, Zaidan, H, Bejan, D, Hoang, NH, Lane, RS, Luoh, S, Leachman, SA, Mills, GB, Gray, JW, Lund, AW, Yantasee, W. In situ tumor vaccination with nanoparticle co-delivering CpG and STAT3 siRNA to effectively induce whole-body anti tumor immune response. 2021. Advanced Materials. 2100628.

Yu, WY, Hill, ST, Chan, ER, Pink, JJ, Cooper, K, Leachman, SA, Lund, AW, Kulkarni, R, Bordeaux, JS. Computational drug repositioning identifies statins as a modifier of prognostic genetic expression signatures and metastatic behavior in melanoma. J Invest Derm 2021 Jan doi: 10.1016/j.jid.2020.12.015.

Soloff, AC, Jones, KE, Powers, AA, Byrne-Steele, M, Wang, Y, Lund, AW, Yuan, J, Monaco, SE, Han, J, Dhupar, R, and Lotze, MT. HMGB1 promotes myeloid egress and limits lymphatic clearance of malignant pleural effusions. Front Immunol. 2020 11:2027.

O’Melia MJ, Lund, AW, Thomas SN. The biophysics of lymphatic transport: Engineering tools and immunological consequences. iScience. 2019 doi: 10/1016/j.sci.2019.11.005.

Goodman JR, Adham ZO, Woltjer RL, Lund AW, Iliff JJ. Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects. Brain Behav Immun. 2018 Oct;73:34-40.

Rambow F, Rogiers A, Marin-Bejar O, Aibar S, Femel J, Dewaele M, Karras P, Brown D, Chang YH, Debiec-Rychter M, Adriaens C, Radaelli E, Wolter P, Bechter O, Dummer R, Levesque M, Piris A, Frederick DT, Boland G, Flaherty KT, van den Oord J, Voet T, Aerts S, Lund AW, Marine JC. Toward minimal residual disease-directed therapy in melanoma. Cell. 2018 Aug 9;174(4):843-855.